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Cat. No.: HY-P5121

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γ-Fibrinogen 377-395

γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.

For research use only. We do not sell to patients.

CAS No.: 957792-67-5
Formula: C₁₀₀H₁₆₅N₂₅O₂₈S₂
Molecular Weight:2229.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

γ-Fibrinogen 377-395 Chemical Structure

CAS No.: 957792-67-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

γ-Fibrinogen377-395 (200 μM) blocks fibrin binding to Mac-1 that inhibits and adhesion of Mac-1-overexpressing cells to immobilized fibrinogen. γ-Fibrinogen377-395 inhibits microglia activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

γ-Fibrinogen377-395 (30 μg/mouse; administered intranasally; once daily for 40 days) increases motor functions of mouse without affecting the peripheral immune response. γ-Fibrinogen377-395 does not affect the coagulation properties of fibrinogen^[1].
Immunized with γ377-395 peptide before EAE induction, γ377-395 peptide-vaccinated mice has an increases in motor strength and coordination compared with control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)^[1]
Dosage:

30 μg/mouse
Administration:

Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE
Result:

Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects.

Chemical Information

CAS No. 957792-67-5
Molecular Weight 2229.66
Formula C₁₀₀H₁₆₅N₂₅O₂₈S₂
Sequence

Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly
Sequence Shortening

YSMKETTMKIIPFNRLSIG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Adams RA, et al. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med. 2007 Mar 19;204(3):571-82. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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