γ-Fibrinogen 377-395 TFA
Based on 1 Customer Validation
γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.
For research use only. We do not sell to patients.
- Purity: 99.55%
- Formula: C102H166F3N25O30S2
- Molecular Weight:2343.68
-
Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
γ-Fibrinogen377-395 TFA (200 μM) blocks fibrin binding to Mac-1 that inhibits and adhesion of Mac-1-overexpressing cells to immobilized fibrinogen. γ-Fibrinogen377-395 TFA inhibits microglia activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Immunized with γ377-395 peptide before EAE induction, γ377-395 peptide-vaccinated mice has an increases in motor strength and coordination compared with control[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)[1]
-
Dosage:30 μg/mouse
-
Administration:Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE
-
Result:Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects.
Chemical Information
-
Appearance Solid
-
Molecular Weight 2343.68
-
Formula C102H166F3N25O30S2
-
Color White to off-white
-
Sequence
Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly
-
Sequence Shortening
YSMKETTMKIIPFNRLSIG
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (21.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4267 mL | 2.1334 mL | 4.2668 mL | 10.6670 mL |
| 5 mM | 0.0853 mL | 0.4267 mL | 0.8534 mL | 2.1334 mL | |
| 10 mM | 0.0427 mL | 0.2133 mL | 0.4267 mL | 1.0667 mL | |
| 15 mM | 0.0284 mL | 0.1422 mL | 0.2845 mL | 0.7111 mL | |
| 20 mM | 0.0213 mL | 0.1067 mL | 0.2133 mL | 0.5333 mL |
γ-Fibrinogen 377-395 TFA Related Classifications
HY-P5121A Related Classifications
Powered by Bioz