2. Peptides
  3. γ-Fibrinogen 377-395 TFA

γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.

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γ-Fibrinogen 377-395 TFA Chemical Structure

γ-Fibrinogen 377-395 TFA Chemical Structure

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Other Forms of γ-Fibrinogen 377-395 TFA:

γ-Fibrinogen 377-395 TFA Related Antibodies

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Description

γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1].

In Vitro

γ-Fibrinogen377-395 TFA (200 μM) blocks fibrin binding to Mac-1 that inhibits and adhesion of Mac-1–overexpressing cells to immobilized fibrinogen. γ-Fibrinogen377-395 TFA inhibits microglia activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Fibrinogen 377-395 TFA Related Antibodies
In Vivo

γ-Fibrinogen377-395 TFA (30 μg/mouse; administered intranasally; once daily for 40 days) increases motor functions of mouse without affecting the peripheral immune response. γ-Fibrinogen377-395 TFA does not affect the coagulation properties of fibrinogen[1].
Immunized with γ377-395 peptide before EAE induction, γ377-395 peptide-vaccinated mice has an increases in motor strength and coordination compared with control[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)[1]
Dosage: 30 μg/mouse
Administration: Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE
Result: Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects.
Molecular Weight

2343.68

Formula

C102H166F3N25O30S2
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly
Sequence Shortening

YSMKETTMKIIPFNRLSIG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Fibrinogen 377-395OthersInhibitorinhibitorinhibit

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