1,2,6-Tri-O-galloyl-β-D-glucose

Name: 1,2,6-Tri-O-galloyl-β-D-glucose
Brand: MedChemExpress
SKU: HY-N11285
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Cat. No.: HY-N11285 Pureté: 99.0%: Fiche technique
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1,2,6-Tri-O-galloyl-β-D-glucose is a polygalloylglucose found in the roots and rhizomes of Sanguisorba officinalis.

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1,2,6-Tri-O-galloyl-β-D-glucose Chemical Structure

CAS No. : 79886-49-0

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	Obtenir un devis
50 mg	Obtenir un devis

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•Related Proteins:

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Description

1,2,6-Tri-O-galloyl-β-D-glucose is a polygalloylglucose found in the roots and rhizomes of Sanguisorba officinalis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HCT-8	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
KB	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
TE-671	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]

In Vitro

Sanguisorba officinalis can be used as a haemostatic and an astringent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

636.47

Formule

C₂₇H₂₄O₁₈

CAS No.

79886-49-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(O)=C(C(O)=C1)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COC(C3=CC(O)=C(C(O)=C3)O)=O)O)O)OC(C4=CC(O)=C(C(O)=C4)O)=O

Structure Classification

Initial Source

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (78.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5712 mL	7.8558 mL	15.7117 mL
5 mM	0.3142 mL	1.5712 mL	3.1423 mL
10 mM	0.1571 mL	0.7856 mL	1.5712 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.96 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (1.96 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (1.96 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 99.0%

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Fiche technique (275 KB) SDS (252 KB)

COA (254 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Tanaka T, et al. 7-O-galloyl-(+)-catechin and 3-O-galloylprocyanidin B-3 from Sanguisorba officinalis[J]. Phytochemistry, 1983, 22(11): 2575-2578.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5712 mL	7.8558 mL	15.7117 mL	39.2792 mL
	5 mM	0.3142 mL	1.5712 mL	3.1423 mL	7.8558 mL
	10 mM	0.1571 mL	0.7856 mL	1.5712 mL	3.9279 mL
	15 mM	0.1047 mL	0.5237 mL	1.0474 mL	2.6186 mL
	20 mM	0.0786 mL	0.3928 mL	0.7856 mL	1.9640 mL
	25 mM	0.0628 mL	0.3142 mL	0.6285 mL	1.5712 mL
	30 mM	0.0524 mL	0.2619 mL	0.5237 mL	1.3093 mL
	40 mM	0.0393 mL	0.1964 mL	0.3928 mL	0.9820 mL
	50 mM	0.0314 mL	0.1571 mL	0.3142 mL	0.7856 mL
	60 mM	0.0262 mL	0.1309 mL	0.2619 mL	0.6547 mL