2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. 1-Methyl-1H-pyrrolo[2,3-b]pyridine

1-Methyl-1H-pyrrolopyridine is a 7-azaindole derivative that binds to the EGFR kinase domain. It inhibits the growth of breast cancer cells but shows no activity against lung cancer and liver cancer cells. 1-Methyl-1H-pyrrolopyridine can be used in breast cancer research .

For research use only. We do not sell to patients.

1-Methyl-1H-pyrrolo[2,3-b]pyridine

1-Methyl-1H-pyrrolo[2,3-b]pyridine Chemical Structure

CAS No. : 27257-15-4

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1-Methyl-1H-pyrrolo[2,3-b]pyridine Related Antibodies

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Description

1-Methyl-1H-pyrrolopyridine is a 7-azaindole derivative that binds to the EGFR kinase domain. It inhibits the growth of breast cancer cells but shows no activity against lung cancer and liver cancer cells. 1-Methyl-1H-pyrrolopyridine can be used in breast cancer research [1].

In Vitro

1-Methyl-1H-pyrrolo[2,3-b]pyridine (Compound 1a) (48 h) inhibits MCF-7 cell growth with an IC50 of 179.8 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Methyl-1H-pyrrolo[2,3-b]pyridine Related Antibodies
Molecular Weight

132.16

Formula

C8H8N2
CAS No.
Appearance

Liquid (Density: 1.107 g/cm3)

SMILES

CN1C=CC2=C1N=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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1-Methyl-1H-pyrrolo[2,3-b]pyridine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Methyl-1H-pyrrolo[2,3-b]pyridine27257-15-4EGFREpidermal growth factor receptorErbB-1HER1liver cancer cellsbreast cancerEGFR kinase domainHEPG2 cellsA549liver cancerbreast cancer cellslung cancer cellslung cancerMCF-7 cellInhibitorinhibitorinhibit

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