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Cat. No.: HY-N12619

12R,13S-Dihydroxyfumitremorgin C

12R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAS No.: 111427-99-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

12R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist^[1].

IC₅₀ & Target

LXRα^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38334086]
PC-3	IC₅₀	6.56 μM Compound: 577	Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 38181652]
U-937	IC₅₀	1.82 μM Compound: 577	Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 38181652]

CAS No. 111427-99-7
Molecular Weight 411.45
Formula C₂₂H₂₅N₃O₅
SMILES

COC1=CC(NC2=C3[C@H](O)[C@]4(O)N(C([C@@](CCC5)([H])N5C4=O)=O)[C@H]2/C=C(C)/C)=C3C=C1
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
Marine Microorganism
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.