2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. 12R,13S-Dihydroxyfumitremorgin C

12R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist.

For research use only. We do not sell to patients.

12R,13S-Dihydroxyfumitremorgin C

12R,13S-Dihydroxyfumitremorgin C Chemical Structure

CAS No. : 111427-99-7

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12R,13S-Dihydroxyfumitremorgin C Related Antibodies

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Description

12R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist[1].

IC50 & Target

LXRα[1]
Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
> 50 μM
Compound: 1
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 38334086]
PC-3 IC50
6.56 μM
Compound: 577
Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 38181652]
U-937 IC50
1.82 μM
Compound: 577
Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 38181652]
Molecular Weight

411.45

Formula

C22H25N3O5
CAS No.
SMILES

COC1=CC(NC2=C3[C@H](O)[C@]4(O)N(C([C@@](CCC5)([H])N5C4=O)=O)[C@H]2/C=C(C)/C)=C3C=C1
Structure Classification
Initial Source

Marine Microorganism
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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12R,13S-Dihydroxyfumitremorgin C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12R,13S-Dihydroxyfumitremorgin C111427-99-7LXRLiver X receptorInhibitorinhibitorinhibit

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