2',3'-Didehydro-2',3'-dideoxyuridine
2',3'-Didehydro-2',3'-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 5974-93-6
- Formula: C9H10N2O4
- Molecular Weight:210.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ATH-8 cell line | ED50 |
>100 μM
Compound: 2d
|
Protection of ATH8 cells against the cytopathic effect of HIV.
Protection of ATH8 cells against the cytopathic effect of HIV.
|
[PMID: 3497272] |
| CCRF-CEM | CC50 |
207 μM
Compound: d4u
|
Cytotoxicity against CEM/0 cells
Cytotoxicity against CEM/0 cells
|
[PMID: 17485204] |
| MT4 | ED50 |
>20 μM
Compound: d4Urd
|
Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
|
[PMID: 2342078] |
Chemical Information
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CAS No. 5974-93-6
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Molecular Weight 210.19
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Formula C9H10N2O4
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SMILES
OC[C@@H]1C=C[C@H](N2C(NC(C=C2)=O)=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)