2-Amino-6-bromopyridine
Based on 1 Customer Validation
2-Amino-6-bromopyridine is an intermediate. 2-Amino-6-bromopyridine is also a PqsR ligand with a Kd value of 6.8 μM in SPR assay. 2-Amino-6-bromopyridine shows weak antagonistic activity. 2-Amino-6-bromopyridine can be used in the synthesis of JAK2 inhibitors, MSK1 inhibitors, and in the research of Pseudomonas aeruginosa infection.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 19798-81-3
- Formula: C5H5BrN2
- Molecular Weight:173.01
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Biological Activity
2-Amino-6-bromopyridine (Compound 7) exhibits binding affinity to PqsR, with a Kd of 6.8 µM (in SPR)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 19798-81-3
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Appearance Solid
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Molecular Weight 173.01
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Formula C5H5BrN2
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Color Off-white to light brown
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SMILES
NC1=NC(Br)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 200 mg/mL (1155.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Michael Zender, et al. Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence. J Med Chem. 2013 Sep 12;56(17):6761-74. [Content Brief]
[2]. Siu M, et al. 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors. Bioorg Med Chem Lett. 2013 Sep 1;23(17):5014-21. [Content Brief]
[3]. Wang J, et al. Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents. Sci Rep. 2017 Mar 23;7:45145. [Content Brief]
[4]. Bollenbach M, et al. Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model. Molecules. 2021 Jan 13;26(2):391. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7799 mL | 28.8996 mL | 57.7991 mL | 144.4978 mL |
| 5 mM | 1.1560 mL | 5.7799 mL | 11.5598 mL | 28.8996 mL | |
| 10 mM | 0.5780 mL | 2.8900 mL | 5.7799 mL | 14.4498 mL | |
| 15 mM | 0.3853 mL | 1.9266 mL | 3.8533 mL | 9.6332 mL | |
| 20 mM | 0.2890 mL | 1.4450 mL | 2.8900 mL | 7.2249 mL | |
| 25 mM | 0.2312 mL | 1.1560 mL | 2.3120 mL | 5.7799 mL | |
| 30 mM | 0.1927 mL | 0.9633 mL | 1.9266 mL | 4.8166 mL | |
| 40 mM | 0.1445 mL | 0.7225 mL | 1.4450 mL | 3.6124 mL | |
| 50 mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.8900 mL | |
| 60 mM | 0.0963 mL | 0.4817 mL | 0.9633 mL | 2.4083 mL | |
| 80 mM | 0.0722 mL | 0.3612 mL | 0.7225 mL | 1.8062 mL | |
| 100 mM | 0.0578 mL | 0.2890 mL | 0.5780 mL | 1.4450 mL |
2-Amino-6-bromopyridine Related Classifications
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