19798-81-3
19798-81-3
Chemical Structure
2-Amino-6-bromopyridine
- CAS No.: 19798-81-3
- Formula:C5H5BrN2
- Molecular Weight:173.01
IUPAC Name: 6-bromopyridin-2-amine
InChIKey: BKLJUYPLUWUEOQ-UHFFFAOYSA-N
SMILES: NC1=NC(Br)=CC=C1
Biological Activity: 2-Amino-6-bromopyridine is an intermediate. 2-Amino-6-bromopyridine is also a PqsR ligand with a Kd value of 6.8 μM in SPR assay. 2-Amino-6-bromopyridine shows weak antagonistic activity. 2-Amino-6-bromopyridine can be used in the synthesis of JAK2 inhibitors, MSK1 inhibitors, and in the research of Pseudomonas aeruginosa infection[1][2][3][4].
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2-Amino-6-bromopyridine | 99.77% | 2-Amino-6-bromopyridine is an intermediate. 2-Amino-6-bromopyridine is also a PqsR ligand with a Kd value of 6.8 μM in SPR assay. 2-Amino-6-bromopyridine shows weak antagonistic activity. 2-Amino-6-bromopyridine can be used in the synthesis of JAK2 inhibitors, MSK1 inhibitors, and in the research of Pseudomonas aeruginosa infection. | ||||||||||||||||||||
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References
- [1]. Michael Zender, et al. Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence. J Med Chem. 2013 Sep 12;56(17):6761-74. [Content Brief]
- [2]. Siu M, et al. 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors. Bioorg Med Chem Lett. 2013 Sep 1;23(17):5014-21. [Content Brief]
- [3]. Wang J, et al. Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents. Sci Rep. 2017 Mar 23;7:45145. [Content Brief]
- [4]. Bollenbach M, et al. Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model. Molecules. 2021 Jan 13;26(2):391. [Content Brief]
