Dimethylpropiothetin hydrochloride-d6
Based on 1 Customer Validation
Dimethylpropiothetin hydrochloride-d6 (s,s-Dimethyl-β-propionic acid thetine-d6) is the d6-labeled Dimethylpropiothetin hydrochloride (HY-W105506). Dimethylpropiothetin hydrochloride is a dimethylsulfide precursor. Dimethylpropiothetin hydrochloride can be isolated from the marine coccolithophore Hymenomonas carterae. Dimethylpropiothetin hydrochloride participates in the maintenance of cellular osmotic pressure.
For research use only. We do not sell to patients.
- Purity : 99.70%
- CAS No.: 1246274-70-3
- Formula: C5H5D6ClO2S
- Molecular Weight:176.69
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246274-70-3
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Unlabeled CAS 4337-33-1
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Appearance Solid
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Molecular Weight 176.69
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Formula C5H5D6ClO2S
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Color White to off-white
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SMILES
[2H]C([S+](CCC(O)=O)C([2H])([2H])[2H])([2H])[2H].[Cl-]
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Synonyms
s,s-Dimethyl-β-propionic acid thetine-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (282.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.6596 mL | 28.2981 mL | 56.5963 mL | 141.4907 mL |
| 5 mM | 1.1319 mL | 5.6596 mL | 11.3193 mL | 28.2981 mL | |
| 10 mM | 0.5660 mL | 2.8298 mL | 5.6596 mL | 14.1491 mL | |
| 15 mM | 0.3773 mL | 1.8865 mL | 3.7731 mL | 9.4327 mL | |
| 20 mM | 0.2830 mL | 1.4149 mL | 2.8298 mL | 7.0745 mL | |
| 25 mM | 0.2264 mL | 1.1319 mL | 2.2639 mL | 5.6596 mL | |
| 30 mM | 0.1887 mL | 0.9433 mL | 1.8865 mL | 4.7164 mL | |
| 40 mM | 0.1415 mL | 0.7075 mL | 1.4149 mL | 3.5373 mL | |
| 50 mM | 0.1132 mL | 0.5660 mL | 1.1319 mL | 2.8298 mL | |
| 60 mM | 0.0943 mL | 0.4716 mL | 0.9433 mL | 2.3582 mL | |
| 80 mM | 0.0707 mL | 0.3537 mL | 0.7075 mL | 1.7686 mL | |
| 100 mM | 0.0566 mL | 0.2830 mL | 0.5660 mL | 1.4149 mL |
Dimethylpropiothetin hydrochloride-d6 Related Classifications
HY-W105506S Related Classifications
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Keywords
- Dimethylpropiothetin hydrochloride-d6
- 1246274-70-3
- s,s-Dimethyl-β-propionic acid thetine-d6
- Isotope-Labeled Compounds
- Drug Intermediate
- enzymatic substrate
- homocysteine
- dimethylsulfide
- marine coccolithophorid phytoplankton
- Hymenomonas carterae
- zwitterionic compatible osmotic solute
- acrylic acid
- Inhibitor
- inhibitor
- inhibit