3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone is a nature product that could be isolated from the fruits of Vitex rotundifolia. 3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone has potent cytotoxic activity against A549 and HepG-2 cell lines.
For research use only. We do not sell to patients.
- CAS No.: 90850-99-0
- Formula: C18H18O7
- Molecular Weight:346.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
2870 ng/mL
Compound: 11
|
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 11975496] |
| PC-12 | GI50 |
2270 ng/mL
Compound: 11
|
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 11975496] |
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone (compound 10; 36 h) has cytotoxic activity with IC50 values of 35 and >100 μM for HepG-2 and A549 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 90850-99-0
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Molecular Weight 346.33
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Formula C18H18O7
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SMILES
COC1=CC=C([C@@H]2CC(C3=C(C(OC)=C(OC)C=C3O2)O)=O)C=C1O
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)