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Cat. No.: HY-46871

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3,9-Dimethyl-3,9-diazaspiro[5.5]undecane

3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid PROTAC linker can be used in the synthesis of PROTACs, such as FIP22 (HY-175764). FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity.

For research use only. We do not sell to patients.

CAS No.: 93004-48-9
Formula: C₁₁H₂₂N₂
Molecular Weight:182.31

Storage:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

3,9-Dimethyl-3,9-diazaspiro[5.5]undecane Chemical Structure

CAS No.: 93004-48-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PROTAC Linkers Isoforms :

Chemical Information

CAS No. 93004-48-9
Appearance Liquid
Molecular Weight 182.31
Formula C₁₁H₂₂N₂
Color Colorless to light yellow
SMILES

CN(CC1)CCC21CCN(C)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fan Y, et al. Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Aug 28;68(16):17874-17896. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

3,9-Dimethyl-3,9-diazaspiro[5.5]undecane

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3,9-Dimethyl-3,9-diazaspiro[5.5]undecane

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

3,9-Dimethyl-3,9-diazaspiro[5.5]undecane Related Classifications

HY-46871 Related Classifications

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