(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research.
For research use only. We do not sell to patients.
- CAS No.: 1180504-64-6
- Formula: C16H16O3
- Molecular Weight:256.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Alkaline phosphatase (ALP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 13
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 19689125] |
| B16-BL6 | IC50 |
>100 μM
Compound: 13
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Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
|
[PMID: 19689125] |
| HeLa | IC50 |
>100 μM
Compound: 13
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
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[PMID: 19689125] |
| HT-1080 | IC50 |
79.6 μM
Compound: 13
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Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
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[PMID: 19689125] |
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane (10 μM) significantly promotes MSCs osteogenic differentiation by increasing the level of alkaline phosphatase (ALP) activity which indicated early-stage of osteoblast differentiation to percent of 162.0 ± 1.4 in relative to the control[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1180504-64-6
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Molecular Weight 256.30
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Formula C16H16O3
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SMILES
OC1=CC=C(C[C@@H](CC2=CC=C(O)C=C2)CO3)C3=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane Related Classifications
HY-N8917 Related Classifications
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