2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 4',5'-Didehydro-5'-deoxyuridine

4',5'-Didehydro-5'-deoxyuridine  (Synonyms: 1-(5-Deoxy-beta-D-erythro-pent-4-enofuranosyl)uracil)

Cat. No.: HY-77645 Purity: ≥95.0%
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4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

4',5'-Didehydro-5'-deoxyuridine Chemical Structure

4',5'-Didehydro-5'-deoxyuridine Chemical Structure

CAS No. : 14365-63-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 100 In-stock
50 mg USD 260 In-stock
100 mg USD 420 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

4',5'-Didehydro-5'-deoxyuridine Related Antibodies

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Description

4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molecular Weight

226.19

Formula

C9H10N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=C1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (442.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4211 mL 22.1053 mL 44.2106 mL
5 mM 0.8842 mL 4.4211 mL 8.8421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4211 mL 22.1053 mL 44.2106 mL 110.5265 mL
5 mM 0.8842 mL 4.4211 mL 8.8421 mL 22.1053 mL
10 mM 0.4421 mL 2.2105 mL 4.4211 mL 11.0527 mL
15 mM 0.2947 mL 1.4737 mL 2.9474 mL 7.3684 mL
20 mM 0.2211 mL 1.1053 mL 2.2105 mL 5.5263 mL
25 mM 0.1768 mL 0.8842 mL 1.7684 mL 4.4211 mL
30 mM 0.1474 mL 0.7368 mL 1.4737 mL 3.6842 mL
40 mM 0.1105 mL 0.5526 mL 1.1053 mL 2.7632 mL
50 mM 0.0884 mL 0.4421 mL 0.8842 mL 2.2105 mL
60 mM 0.0737 mL 0.3684 mL 0.7368 mL 1.8421 mL
80 mM 0.0553 mL 0.2763 mL 0.5526 mL 1.3816 mL
100 mM 0.0442 mL 0.2211 mL 0.4421 mL 1.1053 mL
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4',5'-Didehydro-5'-deoxyuridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4',5'-Didehydro-5'-deoxyuridine14365-63-01-(5-Deoxy-beta-D-erythro-pent-4-enofuranosyl)uracilNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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