2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Betaxolol

Betaxolol 

Cat. No.: HY-B0381 Purity: 99.82%
COA Handling Instructions

Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

For research use only. We do not sell to patients.

Betaxolol Chemical Structure

Betaxolol Chemical Structure

CAS No. : 63659-18-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 63 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 63 In-stock
Solid
5 mg USD 36 In-stock
10 mg USD 57 In-stock
50 mg USD 102 In-stock
100 mg USD 173 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Betaxolol:

Betaxolol Related Antibodies

Top Publications Citing Use of Products

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms
α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

IC50 & Target

Beta1 Adrenergic Receptor
In Vitro

Betaxolol hydrochloride is a cardioselective beta-adrenergic receptor blocking agent.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Betaxolol Related Antibodies
In Vivo

Betaxolol hydrochloride (5 mg/kg via i.p. injection) was administered at 24 and then 44 h following the final chronic cocaine administration. Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal. Betaxolol hydrochloride did not produce anxiolytic-like effects in control animals treated chronically with saline [1]. Betaxolol hydrochloride produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol hydrochloride may be relatively safer to use in patients with reactive airway disease than either timolol or levobunolol [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

307.43

Appearance

Solid

Formula

C18H29NO3
CAS No.
SMILES

OC(CNC(C)C)COC1=CC=C(CCOCC2CC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (325.28 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2528 mL 16.2639 mL 32.5277 mL
5 mM 0.6506 mL 3.2528 mL 6.5055 mL
10 mM 0.3253 mL 1.6264 mL 3.2528 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.13 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.82%

COA (241 KB) HNMR (253 KB) LCMS (250 KB)

Handling Instructions (2659 KB)
References
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Betaxolol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Betaxolol63659-18-7Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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