1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Betaxolol hydrochloride

Betaxolol hydrochloride (Synonyms: SL75212)

Cat. No.: HY-B0381A Purity: 98.94%
Handling Instructions

Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

For research use only. We do not sell to patients.

Betaxolol hydrochloride Chemical Structure

Betaxolol hydrochloride Chemical Structure

CAS No. : 63659-19-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 57 In-stock
Estimated Time of Arrival: December 31
10 mg USD 52 In-stock
Estimated Time of Arrival: December 31
50 mg USD 93 In-stock
Estimated Time of Arrival: December 31
100 mg USD 157 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Betaxolol hydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Betaxolol hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

IC50 & Target

Beta1 Adrenergic Receptor

In Vitro

Betaxolol hydrochloride is a cardioselective beta-adrenergic receptor blocking agent.

In Vivo

Betaxolol hydrochloride (5 mg/kg via i.p. injection) was administered at 24 and then 44 h following the final chronic cocaine administration. Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by increased time spent in the open arms and increased entries into the open arms compared to animals treated with only saline during cocaine withdrawal. Betaxolol hydrochloride did not produce anxiolytic-like effects in control animals treated chronically with saline [1]. Betaxolol hydrochloride produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol hydrochloride may be relatively safer to use in patients with reactive airway disease than either timolol or levobunolol [2].

Clinical Trial
Molecular Weight

343.89

Formula

C₁₈H₃₀ClNO₃

CAS No.

63659-19-8

SMILES

OC(CNC(C)C)COC1=CC=C(CCOCC2CC2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (290.79 mM)

H2O : 10 mg/mL (29.08 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9079 mL 14.5395 mL 29.0791 mL
5 mM 0.5816 mL 2.9079 mL 5.8158 mL
10 mM 0.2908 mL 1.4540 mL 2.9079 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.27 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BetaxololSL75212SL 75212SL-75212Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Betaxolol hydrochloride
Cat. No.:
HY-B0381A
Quantity:
MCE Japan Authorized Agent: