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Cat. No.: HY-15264

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MC 1046

Name: MC 1046
Brand: MedChemExpress
SKU: HY-15264
Price: 310.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Impurity A of Calcipotriol)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

MC 1046 (Impurity A of Calcipotriol) is a hepatic metabolite and an impurity of Calcipotriol (HY-10001). MC 1046 induces differentiation of histiocytic lymphoma cells. MC 1046 can be used for the research of histiocytic lymphoma.

For research use only. We do not sell to patients.

Purity : 95%
CAS No.: 126860-83-1
Formula: C₂₇H₃₈O₃
Molecular Weight:410.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MC 1046 Chemical Structure

CAS No.: 126860-83-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

MC 1046 (96 h) shows no measurable proliferation inhibition at concentrations up to 1.0×10^-7 M and shows a differentiation-inducing concentration of 1.0×10^-7 M in U 937 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human histiocytic lymphoma U 937 cells
Concentration:

1.0×10^-7 M
Incubation Time:

96 h
Result:

Did not inhibit U 937 cell proliferation at the highest tested concentration of 1.0×10^-7 M, resulting in an IC₅₀ >1.0×10^-7 M.
Induced cell differentiation at 1.0×10^-7 M.

In Vivo

MC 1046 is a major serum metabolite of Calcipotriol (MC 903) in healthy male Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 126860-83-1
Appearance Solid
Molecular Weight 410.59
Formula C₂₇H₃₈O₃
Color Off-white to yellow
SMILES

C[C@]1(CCC/2)C(C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C)CC[C@@H]1[C@H](C)/C=C/C(C4CC4)=O
Synonyms

Impurity A of Calcipotriol
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Steroid Biochem Mol Biol

Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells. [Abstract]

2019 Apr:188:172-184. PMID: 30562554

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (121.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4355 mL

12.1776 mL

24.3552 mL

5 mM

0.4871 mL

2.4355 mL

4.8710 mL

10 mM

0.2436 mL

1.2178 mL

2.4355 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kissmeyer AM, et al. Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3. Biochem Pharmacol. 1991 Jun 1;41(11):1601-6. [Content Brief]

[2]. Crankshaw DL, et al. Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes. Biochem Pharmacol. 1990 Jan 15;39(2):393-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4355 mL	12.1776 mL	24.3552 mL	60.8880 mL
	5 mM	0.4871 mL	2.4355 mL	4.8710 mL	12.1776 mL
	10 mM	0.2436 mL	1.2178 mL	2.4355 mL	6.0888 mL
	15 mM	0.1624 mL	0.8118 mL	1.6237 mL	4.0592 mL
	20 mM	0.1218 mL	0.6089 mL	1.2178 mL	3.0444 mL
	25 mM	0.0974 mL	0.4871 mL	0.9742 mL	2.4355 mL
	30 mM	0.0812 mL	0.4059 mL	0.8118 mL	2.0296 mL
	40 mM	0.0609 mL	0.3044 mL	0.6089 mL	1.5222 mL
	50 mM	0.0487 mL	0.2436 mL	0.4871 mL	1.2178 mL
	60 mM	0.0406 mL	0.2030 mL	0.4059 mL	1.0148 mL
	80 mM	0.0304 mL	0.1522 mL	0.3044 mL	0.7611 mL
	100 mM	0.0244 mL	0.1218 mL	0.2436 mL	0.6089 mL

Bioz

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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MC 1046

Publications Citing Use of MedChemExpress (MCE) MC 1046