2. Natural Products
  3. Plants
  4. Labiatae
  5. Clerodendrum infortunatum Dennst.

Clerodendrum infortunatum Dennst.

Clerodendrum infortunatum Dennst. (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N20639
    Clerodin 464-71-1
    Clerodin (3-deoxycaryoptinol) is a natural diterpenoid compound that can be isolated from traditional Chinese medicinal plants such as Clerodendrum infortunatum. Clerodin exhibits caspase-3 regulation, apoptosis induction, cell cycle arrest, ROS induction and glutathione depletion effects, along with anti-cancer and antifeedant activities. It shows selective cytotoxicity against leukemia cells and breast cancer cells, but has no obvious toxicity to normal human blood cells and lymphocytes. Clerodin significantly upregulates the expression of caspase-3 and promotes its activation, induces cell cycle arrest at the G2/M phase, increases intracellular ROS levels and reduces the content of reduced glutathione. Clerodin also reduces the feeding behavior of Helicoverpa armigera larvae on cabbage leaf discs, but has no significant contact toxicity to these larvae. Clerodin can be used in research related to acute monocytic leukemia and human breast cancer.
    Clerodin