1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. PF-4878691

PF-4878691 (Synonyms: 3M-852A)

Cat. No.: HY-100176 Purity: 99.89%
Handling Instructions

PF-4878691 (3M-852A) is a potent, orally active, and selective Toll-like receptor 7 (TLR7) agonist modelled to dissociate its antiviral and inflammatory activities.

For research use only. We do not sell to patients.

PF-4878691 Chemical Structure

PF-4878691 Chemical Structure

CAS No. : 532959-63-0

Size Price Stock Quantity
1 mg USD 1315 In-stock
Estimated Time of Arrival: December 31
5 mg USD 2104 In-stock
Estimated Time of Arrival: December 31
10 mg USD 3366 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PF-4878691 (3M-852A) is a potent, orally active, and selective Toll-like receptor 7 (TLR7) agonist modelled to dissociate its antiviral and inflammatory activities[1][2].

IC50 & Target

TLR7[1]

Molecular Weight

361.46

Formula

C₁₇H₂₃N₅O₂S

CAS No.

532959-63-0

SMILES

CS(=O)(NCCCCN1C(CC)=NC2=C1C3=CC=CC=C3N=C2N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 19.23 mg/mL (53.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7666 mL 13.8328 mL 27.6656 mL
5 mM 0.5533 mL 2.7666 mL 5.5331 mL
10 mM 0.2767 mL 1.3833 mL 2.7666 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.92 mg/mL (5.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.92 mg/mL (5.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.92 mg/mL (5.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.89%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PF-48786913M-852APF4878691PF 4878691Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PF-4878691
Cat. No.:
HY-100176
Quantity:
MCE Japan Authorized Agent: