532959-63-0
532959-63-0
Chemical Structure
PF-4878691
Synonym(s): 3M-852A
- CAS No.: 532959-63-0
- Formula:C17H23N5O2S
- Molecular Weight:361.46
IUPAC Name: N-(4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl)methanesulfonamide
InChIKey: YZOQZEXYFLXNKA-UHFFFAOYSA-N
SMILES: CS(=O)(NCCCCN1C(CC)=NC2=C1C3=CC=CC=C3N=C2N)=O
Biological Activity: PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].
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PF-4878691 | 99.19% | PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer. | ||||||||||||||||||||
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PF-4878691 (Standard) | ≥98% | PF-4878691 (Standard) is the analytical standard of PF-4878691. This product is intended for research and analytical applications. PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9. [Content Brief]
- [2]. Birmachu W, et al. Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists [J]. BMC immunology, 2007, 8: 1-19.
Keywords
