Others

L1-CIDE-BRM1-13 (Compound 15) is a linker-drug precursor moiety formed by the covalent conjugation of a PROTAC degrader with a linker for degrader-antibody conjugates (DACs). L1-CIDE-BRM1-13 can be used for the synthesis of DACs.

RNA binder 4 is an RNA-binding agent that can be used for the synthesis of MJ-NR-27 (HY-183980). MJ-NR-27 is a bifunctional ribonuclease-targeting chimera (RIBOTAC) small molecule that targets NRAS mRNA containing a G-quadruplex structure, and it can be used in cancer research.

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway.

Parethoxycaine (Intracaine) is an ester-type local anesthetic that possesses dual activities as a non-selective inhibitor and agonist potentiator in smooth muscle, while acting as a mixed-type inhibitor of cytochrome c oxidase at the enzyme level. Parethoxycaine non-competitively inhibits the contraction of guinea pig ileal longitudinal muscle by interfering with transmembrane Ca²⁺ transport (blocking K⁺/CD responses in an equi-effective manner), and potentiates norepinephrine (NA) responses in rat vas deferens by blocking NA uptake and promoting Ca²⁺ mobilization (increasing the maximum amplitude without affecting K⁺ responses). Parethoxycaine inhibits the activity of purified cytochrome c oxidase in a concentration-dependent manner, and can be used in research focusing on Ca²⁺ signal transduction, smooth muscle contraction regulation, and mitochondrial energy metabolism.

TDO-IN-3 (compound 20) is an IDO1/TDO inhibitor with IC₅₀ values of 4.12 and 0.12 μM, respectively.

2,3-Dihydroxypropyl 10-undecenoate-¹³C is the ¹³C-labeled 2,3-Dihydroxypropyl 10-undecenoate.

2,3-Dihydroxypropyl 10-undecenoate-d₂ is the deuterium labeled 2,3-Dihydroxypropyl 10-undecenoate.

pMeO-Bz-SF is a covalent, stereoselective α-chymotrypsin inhibitor with an IC₅₀ value of 133 nM. The (R)-enantiomer of pMeO-Bz-SF ((R)-pMeO-Bz-SF (HY-184117B)) inhibits α-chymotrypsin with an IC₅₀ of 101 nM. The (S)-enantiomer of pMeO-Bz-SF ((S)-pMeO-Bz-SF (HY-184117A)) shows low activity against α-chymotrypsin, with an IC₅₀ of 2965 nM.

(S)-pMeO-Bz-SF, the S isomer of pMeO-Bz-SF (HY-184117A), is a potent covalent serine hydrolase inhibitor with an α-chymotrypsin IC₅₀ of 2.965 μM. (S)-pMeO-Bz-SF covalently modifies α-chymotrypsin residues Ser195, Tyr146, and Ser190. (S)-pMeO-Bz-SF exhibits stereoselective inhibitory activity against α-chymotrypsin.

(R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF (HY-184117), is an α-chymotrypsin inhibitor with an IC₅₀ of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner.

AChE-IN-117 is an AChE/nAChR inhibitor with larvicidal activity against Culex pipiens third-instar larvae. AChE-IN-117 forms stable catalytic site interactions to disrupt cholinergic signaling. AChE-IN-117 binds to its receptor via hydrogen bonding and π-cation interactions to interfere with cholinergic synaptic transmission. AChE-IN-117 induces neurotoxic symptoms including hyperactivity, erratic movement, tremors, paralysis, and larval mortality. AChE-IN-117 can be used for the research of mosquito-borne infectious diseases.

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4.

IMP-2958 is an inactive enantiomeric negative control probe with significantly reduced binding to RAB27A/B-Cys123.IMP-2958 serves as a negative control probe for off-target binding in phenotypic assays related to RAB27A/B studies.IMP-2958 functions as a control for stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction.

E3 Ligase Ligand-linker Conjugate 234 (Compound 84) is a conjugate of an E3 ligase ligand and a linker, which can be used to synthesize PROTACs such as XYD224 (HY-184210).

Z2768276635 is an Arabidopsis thaliana acetohydroxyacid synthase (AHAS) inhibitor with a K_i of 0.12 μM, and a K_d of 0.565 μM.Z2768276635 forms a covalent bond with the Ser653 residue of AtAHAS to inhibit catalytic activity.Z2768276635 can be used for the research of weed herbicide resistance.

CRBN ligand-905 is a naphtholactam-based CRBN E3 ligase ligand used in the design of PTPN2 PROTAC degraders PD-305 (HY-183937).

PTPN2 ligand 4 is a PTPN2 ligand and can be used for the synthesis of PROTACs, such as PD-305 (HY-183937).

CRBN ligand-905-piperidine-cyclobutane-acid is an E3 ligase ligand-linker conjugate, consisting of a ligand based on CRBN and a linker, and can be used for the synthesis of PROTACs, such as PD-305 (HY-183937).

PhenDC3n-az is the azide (-N₃) derivative of PhenDC3 (HY-15594), and it is mainly used for click chemistry-based G-quadruplex binding protein pull-down or in situ labeling studies.

TSSK1 ligand-1 (Compound 9) is a TSSK1 ligand that can be used for the synthesis of PROTACs, such as PROTAC TSSK1 Degrader-1 (HY-184428).