Others

HDAC6 ligand-8 is a HDAC6 ligand that can be used for the synthesis of PROTACs, such as PROTAC HDAC6 degrader 10 (HY-184389).

DSPE-PEG-FAP (DSPE-PEG2000-DRGETGPAC) is a functionalized phospholipid molecule composed of three parts: lipid anchor (DSPE), PEG2000, and a fibroblast activation protein (FAP) targeting peptide. DSPE-PEG-FAP can be used in drug delivery-related research.

RN193 is a type II kinase inhibitor with a human PAK1 IC₅₀ of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states.

NH2-C-Ph-hexyne-C4-NH2 is a PROTAC linker. NH2-C-Ph-hexyne-C4-NH2 can connect the BRD4 ligand JQ1 (HY-13030) with the SYVN1 ligand Clofibric acid (HY-B1415), thereby achieving the degradation of BRD4 via the PROTAC mechanism. NH2-C-Ph-hexyne-C4-NH2 can be used for the synthesis of PROTAC BRD4 Degrader-47 (HY-184455).

E3 Ligase Ligand-linker Conjugate 236 is a conjugate of E3 ligase ligand and linker, which can be used for the synthesis of PROTACs, such as PROTAC EGFR degrader 18 (HY-184497).

DSPE-PEG2000-Mal-Cys-SKIFNIHPOSTP is a PEG compound composed of DSPE and a cysteine-containing polypeptide (Cys-SKIFNIHPOSTP). DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY is commonly used to construct targeted liposomes, LNPs (lipid nanoparticles), micelles, or nanomedicine delivery systems.

HOOC-PEG5-N-(C3H7-isopropyl)-NH2 is a PROTAC linker that can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524).

5-TAMRA-LQIQSWSSSP-PEG2000-DSPE is a PEG compound labeled with the fluorescent group 5-TAMRA. 5-TAMRA-LQIQSWSSSP-PEG2000-DSPE is commonly used to construct targeted liposomes, LNPs (lipid nanoparticles), micelles, or nanomedicine delivery systems.

N-(4-Azidobutyl)-2-chloroacetamide is a PROTAC linker that can be used for the synthesis of PROTACs, such as PROTAC Sirt2 Degrader-1 (HY-103636).

CDK8 ligand 2 is a steroidal CDK8 and CDK19 inhibitor with IC₅₀ values of 16 nM and 8 nM, respectively. CDK8 ligand 2 shows no activity against NEK1 (IC₅₀ >10,000 nM). As a target protein ligand, CDK8 ligand 2 is used for the synthesis of the CDK8 PROTAC degrader (HY-111518).

STING ligand-5 (Compound 4) is a ligand for target protein of PROTAC, which is applicable to the synthesis of PROTAC UNC9036 (HY-158048).

BCL-xL ligand 4 is a BCL-xL ligand that can be used for the synthesis of PROTACs, such as PZ703b (HY-115718), PZ703b TFA (HY-115718A), and PZ703b hydrochloride (HY-115718B).

(S,R,S)-AHPC-CO-PEG2-C5-TsO is an E3 ligase ligand-linker conjugate that can be used to synthesize Gefitinib-based PROTAC 3 (HY-123921).

(S,R,R)-VH032-CO-C8-NH2 (Compound 9) is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as UNC9036 (HY-158048).

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405).

TD-106-PEG3-aniline (Compound 17b) is an aminobenzotriazinyl glutarimide analog that binds to cereblon (CRBN). Equipped with a PEG3 linker and an aniline group, TD-106-PEG3-aniline serves as a E3 ligase ligand-Linker conjugates for the synthesis of PROTAC TD-428 (HY-114407).

(2S,10S,19S)-Amine-(CO-CH2-N-Me)9-CO-CH2-CH(NH-CO-CH2-CH2-2-piperidone-tetrahydropyran-pyrimidine-SO2-cyclopentane)-(CO-NH-CH2)2-CO-NH-CH(CH2-benzene)-(CO-NH-CH2)2-O-CH(cyclopropane)-COOH-7-MAD-MDCPT-d₂ is the deuterium labeled (2S,10S,19S)-Amine-(CO-CH2-N-Me)9-CO-CH2-CH(NH-CO-CH2-CH2-2-piperidone-tetrahydropyran-pyrimidine-SO2-cyclopentane)-(CO-NH-CH2)2-CO-NH-CH(CH2-benzene)-(CO-NH-CH2)2-O-CH(cyclopropane)-COOH-7-MAD-MDCPT.

DOPE-PEG1000-cRGD is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 1000 Da, and cyclic RGD peptide (cyclo(Arg-Gly-Asp)) as the terminal targeting/functional ligand. DOPE-PEG1000-cRGD can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against αvβ3/αvβ5 integrins on tumor vasculature and cancer cell surfaces.

DOPE-PEG2000-cRGD is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and cyclic RGD peptide (cyclo(Arg-Gly-Asp)) as the terminal targeting/functional ligand. DOPE-PEG2000-cRGD can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against αvβ3/αvβ5 integrins on tumor vasculature and cancer cell surfaces.

DOPE-PEG3400-cRGD is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 3400 Da, and cyclic RGD peptide (cyclo(Arg-Gly-Asp)) as the terminal targeting/functional ligand. DOPE-PEG3400-cRGD can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against αvβ3/αvβ5 integrins on tumor vasculature and cancer cell surfaces.