BCL-xL ligand 4
BCL-xL ligand 4 is a BCL-xL ligand that can be used for the synthesis of PROTACs, such as PZ703b (HY-115718), PZ703b TFA (HY-115718A), and PZ703b hydrochloride (HY-115718B).
For research use only. We do not sell to patients.
- CAS No.: 3027548-08-6
- Formula: C47H56ClF3N6O6S3
- Molecular Weight:989.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Bcl-xL |
Chemical Information
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CAS No. 3027548-08-6
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Molecular Weight 989.63
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Formula C47H56ClF3N6O6S3
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SMILES
ClC1=CC=C(C=C1)C2=C(C[C@](CN)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(C=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yi Xu, et al. Mivebresib synergized with PZ703b, a novel Bcl-xl PROTAC degrader, induces apoptosis in bladder cancer cells via the mitochondrial pathway. Biochem Biophys Res Commun. 2022 Oct 1;623:120-126. [Content Brief]
[2]. Pratik Pal, et al. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition. J Med Chem. 2021 Oct 14;64(19):14230-14246. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BCL-xL ligand 4 Related Classifications
HY-184547 Related Classifications
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