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Cat. No.: HY-184430

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HDAC6 ligand-8

HDAC6 ligand-8 is a HDAC6 ligand that can be used for the synthesis of PROTACs, such as PROTAC HDAC6 degrader 10 (HY-184389).

For research use only. We do not sell to patients.

Formula: C₂₂H₂₃BrN₂O₅
Molecular Weight:475.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6 ligand-8 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

HDAC6 ligand-8 is a HDAC6 ligand that can be used for the synthesis of PROTACs, such as PROTAC HDAC6 degrader 10 (HY-184389)^[1].

IC₅₀ & Target^[1]

HDAC6

All HDAC Isoforms :

Chemical Information

Molecular Weight 475.33
Formula C₂₂H₂₃BrN₂O₅
SMILES

O=C(C1=CC=C2CN(C(C3CCOCC3)=O)[C@@H](C4=CC=C(Br)C=C4)COC2=C1)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ripa L, et al. Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6 . ACS medicinal chemistry letters. 2026 Jun 11;17(6):1294-1302. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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