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  3. Biochemical Assay Reagents Drug Derivative
  4. PF-7845yne

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway.

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PF-7845yne

PF-7845yne Chemical Structure

CAS No. : 1020321-13-4

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PF-7845yne Related Antibodies

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Description

PF-7845yne is a clickable analogue of PF-7845. PF-7845yne serves as a pharmacological probe to investigate effects of targeting the FAAH-anandamide pathway[1].

In Vitro

PF-7845yne (0.1-10000 nM; 30 min) potently and selectively inhibits mouse brain membrane FAAH, mirroring the activity of its parent compound PF-7845, with no activity against MAGL or ABHD6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-7845yne Related Antibodies
In Vivo

PF-7845yne (0.01-12.5 mg/kg; i.p.; single dose) potently and selectively inhibits brain FAAH activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6J mice[1]
Dosage: 0.01; 0.05; 0.25; 1.25; 6.25; 12.5 mg/kg
Administration: i.p.; single dose
Result: Completely inhibited brain fatty acid amide hydrolase (FAAH) activity at doses as low as 0.05 mg/kg.
Confirmed complete selectivity toward FAAH in mouse brain membrane and soluble proteomes, with no detectable off-target labeling at any tested dose.
Molecular Weight

469.53

Formula

C27H27N5O3
CAS No.
SMILES

O=C(N1CC/C(CC1)=C\C2=CC(OC3=NC=C(C=C3)OCCCC#C)=CC=C2)NC4=NN=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-7845yne Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-7845yne1020321-13-4Biochemical Assay ReagentsDrug DerivativeDrug derivativeFAAHanandamideMAGLpalmitoylethanolamideoleoylethanolamidehumanmouseblood-brain barrierfatty acid amide hydrolaseABHD6Inhibitorinhibitorinhibit

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HY-184029
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