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Cat. No.: HY-184140

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AChE-IN-117

AChE-IN-117 is an AChE/nAChR inhibitor with larvicidal activity against Culex pipiens third-instar larvae. AChE-IN-117 forms stable catalytic site interactions to disrupt cholinergic signaling. AChE-IN-117 binds to its receptor via hydrogen bonding and π-cation interactions to interfere with cholinergic synaptic transmission. AChE-IN-117 induces neurotoxic symptoms including hyperactivity, erratic movement, tremors, paralysis, and larval mortality. AChE-IN-117 can be used for the research of mosquito-borne infectious diseases.

For research use only. We do not sell to patients.

Formula: C₁₅H₁₁N₇O₂S
Molecular Weight:353.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-117 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

AChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE-IN-117 (compound 7) (11.25-90 µg/mL; 24 h) potently kills third-instar Culex pipiens larvae with an LC₅₀ of 0.16 µg/mL^[1].
AChE-IN-117 binds strongly to homology-modeled Culex pipiens AChE with a binding affinity of -6.70 kcal/mol, forming stable interactions with key active-site residues^[1].
AChE-IN-117 binds to homology-modeled Culex pipiens nAChR with a binding affinity of -5.78 kcal/mol, forming key interactions with critical receptor residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 353.36
Formula C₁₅H₁₁N₇O₂S
SMILES

CC1=NN(C2=C1C(C3=CC=C(C=C3)[N+]([O-])=O)=C(C(N)=N2)C#N)C(N)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nofal HR, et al. Design, synthesis, and insecticidal potency of novel 3-methyl-pyrazole derivatives against Culex pipiens larvae. Sci Rep. 2026;16(1):14699. Published 2026 May 9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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AChE-IN-117

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AChE-IN-117 Related Classifications

HY-184140 Related Classifications