Others

4-Fluorobenzoyl-2,3,5,6-d₄ chloride is the deuterium labeled 4-Fluorobenzoyl chloride.

PXS-4787 is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively.

PXS-6302 is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.

FMOC-3-azido-D-alanine is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

H-D-Tyr(Propargyl)-OH is a click chemistry reagent containing an Azide. H-D-Tyr(Propargyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

H-L-Lys(N3-Gly)-OH hydrochloride is a click chemistry containing an azide group, a lysine derivative. H-L-Lys(N3-Gly)-OH hydrochloride can be incorporated into proteins for click modifications. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

(R,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.

DiSulfo-Cy5 alkyne is a fluorescent dye can be used as a click chemistry reagent.

Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent with methyltetrazine building blocks that is highly reactive towards cyclooctene. Cy3 methyltetrazine is also a tetrazine-modified fluorescent probe that can be used to analyze protein phosphorylation in solution and living cells.

DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only.

2-Azido-adenosine is a click chemistry reagent containing an azide group. 2-Azido-adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

17-Aminogeldanamycin is an active compound.

Mono-Cyclohexyl Phthalate-3,4,5,6-d₄ is the deuterium labeled Mono-Cyclohexyl Phthalate.

Glufosinate-d₃ (hydrochloride) is a deuterium labeled compound.

JB061 is a nonmuscle myosin inhibitor with IC₅₀s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC₅₀>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC₅₀ value of 39 μM.

YEATS4-IN-1 (Compound 4d) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a K_i value of 33 nM.

2-Cyanoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

Adenosine-2-carboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

N3-Methyl-2’-O-methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.