2986326-17-2
2986326-17-2
Chemical Structure
JB061
- CAS No.: 2986326-17-2
- Formula:C19H17NO4
- Molecular Weight:323.34
IUPAC Name: 4-bromo-N-((R)-1-((R)-3-(4-(2-cyanophenyl)piperazin-1-yl)-2-hydroxypropoxy)-3-phenylpropan-2-yl)benzenesulfonamide
InChIKey: MJXJTQZHVWSPLP-UDWIEESQSA-N
SMILES: OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=CC(OC)=C3)C2=O
Biological Activity: JB061 is a nonmuscle myosin inhibitor with IC50s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC50>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC50 value of 39 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JB061 | 99.27% | JB061 is a nonmuscle myosin inhibitor with IC50s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC50>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC50 value of 39 μM. | ||||||||||||||||||||
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