2. Cytoskeleton
  3. Myosin
  4. JB062

JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.

For research use only. We do not sell to patients.

JB062 Chemical Structure

JB062 Chemical Structure

CAS No. : 2417988-00-0

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Based on 1 publication(s) in Google Scholar

JB062 Related Antibodies

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Description

JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].

IC50 & Target

IC50: 1.6 μM (Skeletal muscle myosin), 5.4 μM (Cardiac muscle myosin), and >100 μM (Smooth muscle myosin II)[1]
In Vitro

JB062 (compound 6b; 40 μM; 24 h) inhibits cytokinesis in Cos-7 cells[1].
JB062 (COS-7 cells) has cytotoxic to human cancer cells but not normal cells with a CC10 value of 36 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JB062 Related Antibodies
Molecular Weight

323.34

Formula

C19H17NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=C(OC)C=C3)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JB062 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JB0622417988-00-0JB 062JB-062Myosinmuscle spasticitychronic musculoskeletal painhypertrophic cardiomyopathycytokinesisCOS-7 cellInhibitorinhibitorinhibit

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HY-152206
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