Deubiquitinase Ligand

EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1.

CST967 (Compound 17) is a USP7 PROTAC degrader, and increasing the PROTAC concentration can enhance the degradation rate of USP7. CST967 can be used in cancer research.

USP7 ligand-2 is a target protein ligand that can be used for the synthesis of PROTACs, such as PROTAC USP7 Degrader-2 (HY-180793.

UBTR008295a is a USP5 ZnF-UBD binder with a K_d of 80 μM. UBTR008295a interacts with USP5 ZnF-UBD. UBTR008295a is applicable for cancer research.

MS8572 is a selective OTUB1 covalent ligand. MS8572 covalently modifies the noncatalytic cysteine 23 residue of OTUB1 and does not inhibit OTUB1 deubiquitinase activity. MS8572 can be used for development of deubiquitinase-targeting chimeras for targeted protein stabilization.

MS5105 is a covalent ligand of the deubiquitinating enzyme OTUB1, which can be used to construct DUBTACs, such as MS8588 (HY-162967).

CST967 is a USP7 ligand, which can be used for the synthesis of PROTACs, such as CST967 (HY-160502).