Epoxide Hydrolase
Epoxide hydrolases (EH) present in all living organisms. The mammalian soluble epoxide hydrolase (sEH) is a 120 kDa dimer of two identical 62.5 kDa monomers arranged in an anti-parallel fashion. It is mostly expressed in the liver, kidneys, brain, endothelium, and at lesser levels in other tissues. Inflammation and pain are major components of many disease states. Mammalian sEH inhibition reduces blood pressure, inflammation and pain. The anti-inflammatory activities of sEH inhibitors occur in part through the NF-κB mediated down-regulation of COX2 transcription, resulting in lower production of pro-inflammatory prostaglandins such as PGE2 and PGD2.
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Epoxide Hydrolase Related Products (94)
Related Products (94)
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Antibodies (1)
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1,3-Dicyclohexylurea
0 Images1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats.
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ARM1
0 ImagesSynonyms: 4BSAARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC50 7.61 µM and epoxide hydrolase inhibitory activity with an IC50 12.4 µM.
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sEH inhibitor-7
0 ImagessEH inhibitor-7 is an sEH inhibitor, with an IC50 of 0.15 μM against mouse sEH and an IC50 of 6.2 μM against h-sEH. sEH inhibitor-7 can be used in studies related to hypertension and inflammation.
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1,3-Dibenzylurea
0 ImagesCat. No.: HY-W097200CAS No.: 1466-67-7Synonyms: N,N′-Dibenzylurea1,3-Dibenzylurea is an insect growth regulator and a mouse soluble epoxide hydrolase (MsEH) inhibitor.
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1,3-Dicyclohexylurea (Standard)
0 Images1,3-Dicyclohexylurea (Standard) is the analytical standard of 1,3-Dicyclohexylurea. This product is intended for research and analytical applications. 1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats.
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CUDA disodium
0 ImagesCat. No.: HY-121538APurity: 98.0%CUDA disodium is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA disodium selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA disodium may be valuable for the research of cardiovascular disease.
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sEH inhibitor-1
0 ImagessEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.
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(Rac)-EC5026
0 ImagesSynonyms: (Rac)-BPN-19186(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB).
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PAL-4
0 ImagesPAL-4 (compound 4) is a potent, selective and reversible Lysophospholipase-like 1 (LYPLAL1) activator with EC50 value of 0.39 μM and 0.49 μM for mice LYPLAL1 and huamn LYPLAL1, respectively. PAL-4 can be used for researching metabolic disorders.
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S-NEPC
0 ImagesSynonyms: 4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonateS-NEPC (4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate) is a colorimetric substrate used to measure epoxide hydrolase activity.
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1-Cyclohexyl-3-dodecyl urea
0 ImagesSynonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.
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sEH/FXR-IN-1
0 ImagesCat. No.: HY-W104814CAS No.: 59089-68-8sEH/FXR-IN-1 (compound 9) is a soluble epoxide hydrolase (sEH) and FXR ligand.
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sEH inhibitor-19
0 ImagesCat. No.: HY-170492CAS No.: 3107483-12-2sEH inhibitor-19 (Compound (R)-14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan (HY-125474)-induced edema models.
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DJ-53
0 ImagesCat. No.: HY-168144DJ-53 (compund 68) is an orally active phenylquinoline-based soluble epoxide hydrolase inhibitor.
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sEH inhibitor-17
0 ImagesCat. No.: HY-159121CAS No.: 2823295-37-8sEH inhibitor-17 (compound 4f) is an oral active soluble epoxide hydrolase (sEH) inhibitor with the IC50 of 2.94 nM. sEH inhibitor-17 shows anti-inflammatory efficacy.
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sEH inhibitor-6
0 ImagesCat. No.: HY-148000CAS No.: 1205963-04-7sEH inhibitor-6 (Compound 3g) is a soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 0.5 nM.
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sEH inhibitor-16
0 ImagesCat. No.: HY-155029CAS No.: 2999636-75-6sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.
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Thalictoside
0 ImagesCat. No.: HY-N15524CAS No.: 74213-96-0Thalictoside is found in A. squamosa L. Thalictoside is a sEH inhibitor (IC50: 20.2 µM). Thalictoside exerts anti-osteoporotic effects through an estrogen-like mechanism. Thalictoside can be used in the research of cardiovascular and urinary diseases.
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(E)-3-Feruloylquinic acid
0 ImagesCat. No.: HY-W587945CAS No.: 87099-72-7Synonyms: (E)-3-O-Feruloylquinic acid(E)-3-Feruloylquinic acid (Compound 3) is a chlorogenic acid. (E)-3-Feruloylquinic acid can be isolated from the aerial parts of Tetrastigma hemsleyanum. (E)-3-Feruloylquinic acid inhibits soluble epoxide hydrolase (sEH) with an IC50 of 60.7 μM. (E)-3-Feruloylquinic acid can be used in the study of vascular system diseases.
