2. Signaling Pathways
  3. Epigenetics
  4. Histone Acetyltransferase
  5. CBP/p300 Isoform
  6. CBP/p300 Activator

CBP/p300 Activator

CBP/p300 Activators (6):

Cat. No. Product Name Effect Purity
  • HY-134964
    CTB
    		Activator 99.76%
    CTB is a potent p300 histone acetyltransferase activator. CTB can effectively induce apoptosis in MCF-7 cells.
  • HY-16531
    YF-2
    		Activator 99.44%
    YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
  • HY-116673
    TTK21
    		Activator 99.43%
    TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory.CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function. CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model.
  • HY-124960
    CTPB
    		Activator ≥99.0%
    CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme.
  • HY-19541
    I-CBP112
    		Activator 98.46%
    I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that inhibits the CBP/p300 bromodomains, enhances acetylation by p300.
  • HY-16531A
    YF-2 hydrochloride
    		Activator 99.61%
    YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.