2. Signaling Pathways
  3. Immunology/Inflammation
  4. IFNAR
  5. IFNAR Modulator

IFNAR Modulator

IFNAR Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-178716
    PTPN2/1-IN-4
    		Modulator
    PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models.