153840-64-3
Chemical Structure
IFN-α Receptor Recognition Peptide 1
Synonym(s): IRRP1
- CAS No.: 153840-64-3
- Formula:C35H59N13O12S
- Molecular Weight:885.99
IUPAC Name: L-cysteinyl-L-leucyl-L-lysyl-L-aspartyl-L-arginyl-L-histidyl-L-aspartic acid
InChIKey: LZLJLCKYBQOTSE-HUVRVWIJSA-N
SMILES: O=C(O)C[C@@H](C(O)=O)NC([C@H](CC1=CNC=N1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CS)N)=O)=O)=O)=O)=O)=O
Biological Activity: IFN-α Receptor Recognition Peptide 1 (IRRP1) is an amino acid synthetic peptide and also a regulator of IFN-α Receptor. IFN-α Receptor Recognition Peptide 1 binds to IFNAR2, enhances the binding capacity of IFN-α receptor, and slightly increases the IFN-α-induced growth inhibitory activity. IFN-α Receptor Recognition Peptide 1 inhibits IFN-α-induced STAT1 phosphorylation and STAT-DNA binding by blocking the activation of IFNAR by IFN-α. IFN-α Receptor Recognition Peptide 1 increases the occupancy of IFN-α on cell surface receptors, enhances the phosphorylation activation of ISGF3, and elevates IFN-α-induced antiviral activity. IFN-α Receptor Recognition Peptide 1 can be used in studies related to encephalomyocarditis virus infection[1][2].
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IFN-α Receptor Recognition Peptide 1 | IFN-α Receptor Recognition Peptide 1 (IRRP1) is an amino acid synthetic peptide and also a regulator of IFN-α Receptor. IFN-α Receptor Recognition Peptide 1 binds to IFNAR2, enhances the binding capacity of IFN-α receptor, and slightly increases the IFN-α-induced growth inhibitory activity. IFN-α Receptor Recognition Peptide 1 inhibits IFN-α-induced STAT1 phosphorylation and STAT-DNA binding by blocking the activation of IFNAR by IFN-α. IFN-α Receptor Recognition Peptide 1 increases the occupancy of IFN-α on cell surface receptors, enhances the phosphorylation activation of ISGF3, and elevates IFN-α-induced antiviral activity. IFN-α Receptor Recognition Peptide 1 can be used in studies related to encephalomyocarditis virus infection. | |||||||||||||||||||||
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