PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4100)
Related Products (4100)
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PROTAC Linkers Isoform Comparison
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Azido-PEG3-phosphonic acid ethyl ester
0 ImagesCat. No.: HY-140813CAS No.: 1337527-24-8Azido-PEG3-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-phosphonic acid ethyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG8-C1-NHS ester
0 ImagesCat. No.: HY-140767CAS No.: 2182601-81-4Azido-PEG8-C1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Benzyl-PEG9-Ots
0 ImagesCat. No.: HY-138712CAS No.: 393517-91-4
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Ms-PEG12-m
0 ImagesCat. No.: HY-115392CAS No.: 1059604-93-1
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m-PEG6-C6-phosphonic acid ethyl ester
0 ImagesCat. No.: HY-141315CAS No.: 2028281-88-9
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m-PEG4-CH2-methyl ester
0 ImagesCat. No.: HY-141404CAS No.: 1920109-55-2
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Methyltetrazine-PEG6-maleimide
0 ImagesCat. No.: HY-133468Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Azido-PEG1-methyl ester
0 ImagesCat. No.: HY-140851CAS No.: 1835759-80-2Azido-PEG1-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Methylamino-PEG5-azide
0 ImagesCat. No.: HY-140159CAS No.: 2055046-24-5Methylamino-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methylamino-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG8-C-Boc
0 ImagesCat. No.: HY-138377CAS No.: 1984776-39-7Azido-PEG8-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-C-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-(m-PEG4)-amidohexanoic acid
0 ImagesCat. No.: HY-140016CAS No.: 2353409-74-0
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N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)
0 ImagesCat. No.: HY-140870CAS No.: 2093152-79-3N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-acrylate-PEG5
0 ImagesCat. No.: HY-W096160CAS No.: 59256-52-9
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Pyrene-PEG2-azide
0 ImagesCat. No.: HY-141092CAS No.: 2135330-58-2Pyrene-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Pyrene-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Carboxyfluorescein-PEG12-NHS
0 ImagesCat. No.: HY-141085CAS No.: 2246595-66-2
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C1-BCEA-Acm
0 ImagesCat. No.: HY-164951CAS No.: 2223042-67-7C1-BCEA-Acm is a linker, that can be used for synthesis of polyubiquitin chains and ubiquitin-modified substrates.
