PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4100)
Related Products (4100)
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PROTAC Linkers Isoform Comparison
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Boc-NH-PEG10-CH2CH2COOH
0 ImagesCat. No.: HY-140471CAS No.: 2410598-01-3
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Benzyl-PEG24-MS
0 ImagesCat. No.: HY-138332CAS No.: 2218463-20-6
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Amino-PEG23-amine
0 ImagesCat. No.: HY-140211CAS No.: 2673284-93-8
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Tetrazine-Ph-NHCO-PEG4-NH-Boc
0 ImagesCat. No.: HY-133462Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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TCO-PEG6-NHS ester
0 ImagesCat. No.: HY-141168CAS No.: 2353409-96-6
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6-Maleimidocaproic acid-PFP ester
0 ImagesCat. No.: HY-140990CAS No.: 692739-25-6
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Benzyl-PEG8-THP
0 ImagesCat. No.: HY-W096066CAS No.: 1611489-00-9
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Ald-Ph-amido-C2-PEG3-NH-Boc
0 ImagesCat. No.: HY-130669CAS No.: 1807540-87-9
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Hydroxy-Amino-bis(PEG2-propargyl)
0 ImagesCat. No.: HY-140082CAS No.: 2100306-77-0Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Hydroxy-Amino-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Thiol-C9-PEG4-acid
0 ImagesCat. No.: HY-138526CAS No.: 716339-41-2
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N-Succinimidyl 3-(Bromoacetamido)propionate
0 ImagesCat. No.: HY-141385CAS No.: 57159-62-3Synonyms: 3-(2-Bromoacetamido)propanoic acid NHS esterN-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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CHO-CH2-PEG1-CH2-Boc
0 ImagesCat. No.: HY-138355CAS No.: 2230956-95-1
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Azide-PEG7-Tos
0 ImagesCat. No.: HY-140354CAS No.: 1418561-41-7Azide-PEG7-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG7-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bromo-PEG4-NHS ester
0 ImagesCat. No.: HY-132017CAS No.: 2148295-98-9
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Hydroxy-PEG12-Boc
0 ImagesCat. No.: HY-130831CAS No.: 2388521-20-6
