PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4103)
Related Products (4103)
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PROTAC Linkers Isoform Comparison
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m-PEG2-Amino
0 ImagesCat. No.: HY-140397CAS No.: 54149-49-4
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Succinamic acid
0 ImagesCat. No.: HY-W037980CAS No.: 638-32-4
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Azido-PEG9-Boc
0 ImagesCat. No.: HY-140780CAS No.: 1818294-43-7Azido-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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(+)-Biotin-PEG2-hydrazide
0 ImagesCat. No.: HY-130892CAS No.: 2413847-26-2
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N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7
0 ImagesCat. No.: HY-141079CAS No.: 2107273-84-5N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Boc-N-bis(PEG3-azide)
0 ImagesCat. No.: HY-140555CAS No.: 1258939-38-6N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Me-N-bis-PEG3
0 ImagesCat. No.: HY-140577CAS No.: 342818-95-5
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Boc-N-Amido-PEG5-MS
0 ImagesCat. No.: HY-140392CAS No.: 2128735-28-2
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Propargyl-PEG11-methane
0 ImagesCat. No.: HY-140061CAS No.: 2250411-18-6
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Phthalimide-PEG4-PDM-OTBS
0 ImagesCat. No.: HY-129773Phthalimide-PEG4-PDM-OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-PDM-OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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m-PEG4-propargyl
0 ImagesCat. No.: HY-113921CAS No.: 1101668-39-6
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N-(Tos-PEG4)-N-bis(PEG4-Boc)
0 ImagesCat. No.: HY-140393CAS No.: 2112737-74-1
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Boc-Aminooxy-PEG1-C2-NH2
0 ImagesCat. No.: HY-140425CAS No.: 1844894-82-1
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Azido-PEG7-NHS ester
0 ImagesCat. No.: HY-138707CAS No.: 2801772-85-8Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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1,1,1-Trifluoroethyl-PEG4-amine
0 ImagesCat. No.: HY-140243CAS No.: 1872433-72-1
