PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4103)
Related Products (4103)
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PROTAC Linkers Isoform Comparison
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DBCO-NHCO-PEG2-NHS ester
0 ImagesCat. No.: HY-133375CAS No.: 2666999-50-2
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N-(Amino-PEG4)-N-bis(PEG4-Boc)
0 ImagesCat. No.: HY-140255CAS No.: 2093153-97-8
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1,1,1-Trifluoroethyl-PEG4-aminooxy
0 ImagesCat. No.: HY-140445CAS No.: 1895922-78-7
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m-PEG3-S-Acetyl
0 ImagesCat. No.: HY-141351CAS No.: 857284-78-7
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Acetamido-PEG3-Br
0 ImagesCat. No.: HY-134706CAS No.: 2710799-07-6
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TCO-PEG4-TCO
0 ImagesCat. No.: HY-141188CAS No.: 2243569-23-3
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m-PEG5-Boc
0 ImagesCat. No.: HY-141396CAS No.: 874208-93-2
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Boc-NH-PEG20-CH2CH2COOH
0 ImagesCat. No.: HY-140473CAS No.: 2941512-86-1
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N3-PEG40000-NH2
0 ImagesCat. No.: HY-W1048572JSynonyms: Azide-PEG40000-AmineN3-PEG40000-NH2 (Azide-PEG40000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG40000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester.
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Iodoacetyl-PEG4-NHS ester
0 ImagesCat. No.: HY-138422CAS No.: 2517899-65-7
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Boc-aminooxy-PEG2-propargyl
0 ImagesCat. No.: HY-140050CAS No.: 1895922-74-3
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N-(Aminooxy-PEG3)-N-bis(PEG4-Boc)
0 ImagesCat. No.: HY-140446CAS No.: 2112737-19-4
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Ms-PEG8-Boc
0 ImagesCat. No.: HY-140385CAS No.: 2097604-01-6
