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Art. -Nr.: HY-133375

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DBCO-NHCO-PEG2-NHS ester

DBCO-NHCO-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG2-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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CAS. Nr.: 2666999-50-2
Formel: C₃₀H₃₁N₃O₈
Molecular Weight:561.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DBCO-NHCO-PEG2-NHS ester Chemical Structure

CAS. Nr.: 2666999-50-2

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- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

DBCO-NHCO-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. DBCO-NHCO-PEG2-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs	Alkyl/ether

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2666999-50-2
Molecular Weight 561.58
Formel C₃₀H₃₁N₃O₈
SMILES

O=C(CCNC(CCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)N2C3=CC=CC=C3C#CC4=CC=CC=C4C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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DBCO-NHCO-PEG2-NHS ester

DBCO-PEG4-NHS ester

DBCO-PEG24-NHS ester

DBCO-PEG5-NHS ester

DBCO-PEG3-NHS

DBCO-PEG2-NHS ester

DBCO-PEG1-NHS ester

DBCO-NHS ester

DBCO-acid

DBCO-NHCO-PEG5-NHS ester

DBCO-NHS ester 2

DBCO-Sulfo-NHS ester sodium

DBCO-CONH-S-S-NHS ester

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

DBCO-NHCO-PEG2-NHS ester

DBCO-PEG4-NHS ester

DBCO-PEG24-NHS ester

DBCO-PEG5-NHS ester

DBCO-PEG3-NHS

DBCO-PEG2-NHS ester

DBCO-PEG1-NHS ester

DBCO-NHS ester

DBCO-acid

DBCO-NHCO-PEG5-NHS ester

DBCO-NHS ester 2

DBCO-Sulfo-NHS ester sodium

DBCO-CONH-S-S-NHS ester

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DBCO-NHCO-PEG2-NHS ester Related Classifications

HY-133375 Related Classifications

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