PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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C5-CONH-C2-N-CH3
0 ImagesCat. No.: HY-163788CAS No.: 1251346-48-1
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Thiol-C9-PEG5
0 ImagesCat. No.: HY-138529CAS No.: 130727-42-3
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PEG2-ethyl acetate
0 ImagesCat. No.: HY-138436CAS No.: 154773-33-8
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Propargyl-PEG13-OH
0 ImagesCat. No.: HY-138735CAS No.: 3127545-21-2
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Ald-Ph-PEG5-Boc
0 ImagesCat. No.: HY-140629CAS No.: 1433996-83-8
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Hydroxy-PEG10-CH2-Boc
0 ImagesCat. No.: HY-133312CAS No.: 2874310-22-0Synonyms: HO-PEG10-CH2COOtBu
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m-PEG3-amido-C3-triethoxysilane
0 ImagesCat. No.: HY-141407CAS No.: 2243566-45-0
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DNP-PEG3-DNP
0 ImagesCat. No.: HY-130350CAS No.: 1365655-92-0
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Thiol-PEG6-acid
0 ImagesCat. No.: HY-133291CAS No.: 1347750-77-9
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HS-PEG7-CH2CH2COOH
0 ImagesCat. No.: HY-130874CAS No.: 2755121-32-3Synonyms: Thiol-PEG7-propionic acid
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Mal-amido-PEG9-NHS ester
0 ImagesCat. No.: HY-138731CAS No.: 2575631-92-2
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S-acetyl-PEG5-alcohol
0 ImagesCat. No.: HY-138748CAS No.: 1000415-61-1
