PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Mal-PEG1-Boc
0 ImagesCat. No.: HY-133162CAS No.: 810677-16-8
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Azido-PEG4-propargyl
0 ImagesCat. No.: HY-132050CAS No.: 1192590-91-2Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Azido-PEG3-MS
0 ImagesCat. No.: HY-138343CAS No.: 176520-24-4Azido-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Benzyl-PEG3-MS
0 ImagesCat. No.: HY-132108CAS No.: 702701-70-0
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Bromo-PEG7-amine hydrobromide
0 ImagesCat. No.: HY-143844B
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Propargyl-PEG4-Sulfone-PEG4-acid
0 ImagesCat. No.: HY-140610CAS No.: 2055024-41-2Propargyl-PEG4-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Azido-PEG12-alcohol
0 ImagesCat. No.: HY-138769CAS No.: 1111239-69-0Azido-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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(2-Pyridyldithio)-PEG2-Boc
0 ImagesCat. No.: HY-141361CAS No.: 2144777-73-9
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N-(PEG2-Boc)-N-bis(PEG2-propargyl)
0 ImagesCat. No.: HY-140093CAS No.: 2100306-69-0N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Thiol-C10-amide-PEG8
0 ImagesCat. No.: HY-138533CAS No.: 1353948-95-4
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Azide-PEG9-amido-C12-Boc
0 ImagesCat. No.: HY-140790Synonyms: 13-(Azide-PEG9-ethylcarbamoyl)tridecanoic t-butyl esterAzide-PEG9-amido-C12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C12-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG5-azide
0 ImagesCat. No.: HY-130168CAS No.: 1202681-04-6m-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Propargyl-PEG7-Boc
0 ImagesCat. No.: HY-130380CAS No.: 1818294-29-9
