ROCK
Rho-associated protein kinase; Rho-associated kinase; Rho-kinase; ROK
ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus, invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, acoiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton.
ROCK Isoform Specific Products
All Product Categories
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ROCK Related Products (204)
Related Products (204)
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Antibodies (12)
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ROCK Isoform Comparison
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HA-100 hydrochloride
0 ImagesCat. No.: HY-100984ACAS No.: 141543-63-7
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Centaureidin
0 ImagesCat. No.: HY-N10341CAS No.: 17313-52-9Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice[1][2][3][4][5].
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SR-3677 dihydrochloride
0 ImagesCat. No.: HY-13300ACAS No.: 1781628-88-3SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC50 values of 56 nM and 3 nM.
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Glycerophosphoinositol 4-phosphate
0 ImagesCat. No.: HY-171909CAS No.: 129830-96-2Synonyms: GroPIns-4-PGlycerophosphoinositol 4-phosphate (GroPIns-4-P) is a metabolite of phospholipase A and an inhibitor of adenylylcyclase. Glycerophosphoinositol 4-phosphate can regulate cAMP-dependent cellular functions. Glycerophosphoinositol 4-phosphate can also induce the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating the small GTPases Rac and Rho, respectively. Glycerophosphoinositol 4-phosphate can be used in research on cancer cell motility and invasiveness.
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AR-13503 (Standard)
0 ImagesCat. No.: HY-12798CRCAS No.: 2309668-15-1Synonyms: AR-13324 M1 metabolite (Standard)Fluanisone (Standard) is the analytical standard of Fluanisone. This product is intended for research and analytical applications. Fluanisone has potent sedative effect in vivo. Fluanisone can be used to study schizophrenia.
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ROCK-IN-D1
0 ImagesCat. No.: HY-123484CAS No.: 1219721-73-9ROCK-IN-D1 serves as a highly effective and selective inhibitor of ROCK.
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(R)-AR-13503
0 ImagesSynonyms: (R)-AR-13324 M1 metabolite(R)-AR-13503 ((R)-AR-13324 M1 metabolite) is the the (R)-enantiomer of AR-13503 (HY-12798C). AR-13503 is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research.
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ROCK2-IN-5
0 ImagesCat. No.: HY-145294CAS No.: 3031515-48-4ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation.
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(Rac)-NRL-1049 dihydrochloride
0 ImagesCat. No.: HY-162596ACAS No.: 863638-93-1Synonyms: (Rac)-BA-1049(Rac)-NRL-1049 is the racemic mixture of NRL-1049 (BA-1049 (free base)) (HY-162596). NRL-1049 is an orally available and selective ROCK2 inhibitor with IC50 values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations.
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Bazipsudil
0 ImagesCat. No.: HY-187858CAS No.: 2292312-76-4Bazipsudil is a potent, selective Rho-associated protein kinase (ROCK) inhibitor.
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CCG-232964
0 ImagesCat. No.: HY-130011CAS No.: 2349373-70-0CCG-232964 is an orally active inhibitor of Rho/MRTF/SRF. CCG-232964 inhibits LPA-induced CTGF gene expression.
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5-Nitro-1H-indazole-3-carbonitrile
0 ImagesCat. No.: HY-W047432CAS No.: 90348-29-1Synonyms: DL08055-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research.
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LASSBio-2389
0 ImagesCat. No.: HY-181583CAS No.: 2671377-38-9LASSBio-2389 is a selective ROCK2 inhibitor with an IC50 of 0.051 μM and an IC50 of 1.143 μM against ROCK1. LASSBio-2389 reduces the viability of MDA-MB-231 cells and inhibits cell migration. LASSBio-2389 is applicable to the research of triple-negative breast cancer.
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HA-100 dihydrochloride
0 ImagesCat. No.: HY-12880CAS No.: 210297-47-5
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WF-536
0 ImagesCat. No.: HY-118837CAS No.: 539857-64-2
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RX-044
0 ImagesCat. No.: HY-187204RX-044 is a ROCK1/ROCK2 inhibitor with ROCK1 IC50 10.01 nM and ROCK2 IC50 9.68 nM, and demonstrates kinase selectivity. RX-044 induces reversible cell retraction, modulates cytoskeletal organization via F-actin depolymerization, inhibits cell contractility, and attenuates TGF-β2-induced cell migration. RX-044 preserves retinal ganglion cell survival, restores electroretinography responses, and ameliorates histopathological changes. RX-044 lowers intraocular pressure in a mouse ocular hypertension model. RX-044 shows no cytotoxicity in target cells. RX-044 exhibits initial ocular irritation that subsides with extended dosing. RX-044 can be used for the research of glaucoma.
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ROCK2-IN-14
0 ImagesCat. No.: HY-181576CAS No.: 3115784-59-0ROCK2-IN-14 is an orally active, selective ROCK2 inhibitor (IC50=4.8 nM) with 212-fold selectivity over ROCK1 (IC50=1.01 μM). By inhibiting the ROCK2/S100A9 signaling pathway, ROCK2-IN-14 downregulates S100A9 expression, inhibits NM2 phosphorylation and restores cytoskeletal abnormalities. Furthermore, ROCK2-IN-14 reduces inflammatory cytokine levels, alleviates skin inflammation and exerts anti-inflammatory activity. ROCK2-IN-14 also significantly inhibits ear thickening in a mouse model of atopic dermatitis (AD), and decreases the levels of IgE, TNF-α, IL-6 and TSLP. ROCK2-IN-14 can be used for research on atopic dermatitis.
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ROCK-IN-11
0 ImagesCat. No.: HY-W295201CAS No.: 445267-51-6
