Ras Inhibitor
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TH-Z827 diTFA
0 ImagesCat. No.: HY-153663BTH-Z827 diTFA is a selective KRASG12D inhibitor that exhibits activity against GDP-bound and GMPPNP-bound KRASG12D, but shows no activity against KRAS (WT) and KRASG12C. TH-Z827 diTFA blocks the KRASG12D-CRAF interaction with a IC50 value of 42 μM. TH-Z827 diTFA can be used for the research of pancreatic cancer.
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NHTD
0 ImagesCat. No.: HY-164513CAS No.: 2540915-70-4NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC).
