2. Signaling Pathways
  3. Apoptosis
  4. TNF Receptor
  5. TNFRSF5/CD40 Isoform
  6. TNFRSF5/CD40 Agonist

TNFRSF5/CD40 Agonist

TNFRSF5/CD40 Agonists (2):

Cat. No. Product Name Effect Purity
  • HY-P991556
    TQB2916
    		Agonist
    TQB2916 is a humanized IgG2 monoclonal antibody agonist targeting CD40. TQB2916 has a significant antitumor activity with CD40 occupancy and immune activation. TQB2916 can be used for advanced solid tumors and lymphomas research.
  • HY-P992408
    MEDI-5083
    		Agonist
    MEDI-5083 is an Fc fusion protein that targets CD40 and is a CD40 agonist. MEDI-5083 stimulates CD40 signaling via NF-κB activation. MEDI-5083 upregulates MHCII, CD80, and CD86 expression, induces pro-inflammatory cytokine secretion, and enhances IFN-γ secretion by memory CD8+ T cells. MEDI-5083 can be used for the research of melanoma, colon carcinoma, and advanced solid tumors[1][2].