Beta-lactamase
β-lactamase
Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.
Beta-lactamase Isoform Specific Products
All Product Categories
-
Beta-lactamase Related Products (254)
Related Products (254)
-
Beta-lactamase Isoform Comparison
-
Metallo-β-lactamase-IN-7
0 ImagesCat. No.: HY-143415CAS No.: 2752453-58-8Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains.
-
NDM-1-IN-13
0 ImagesCat. No.: HY-183935NDM-1-IN-13 is a NDM-1 inhibitor with an IC50 of 3.27 μM. As an Antibiotic synergist, NDM-1-IN-13 synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-positive bacterial isolates. NDM-1-IN-13 can be used in studies related to NDM-1-positive bacterial infections.
-
Metallo-β-lactamase-IN-4
0 ImagesCat. No.: HY-144262CAS No.: 2711044-25-4Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively.
-
Moxalactam
0 ImagesCat. No.: HY-B1484ACAS No.: 64952-97-2Synonyms: Latamoxef; Lamoxactam; LY-127935Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases.
-
Tubastatin A (GMP)
0 ImagesCat. No.: HY-13271AGCAS No.: 1252003-15-8Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
-
Zndm19
0 ImagesCat. No.: HY-155283CAS No.: 364055-05-0Zndm19 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor. Zndm19 can be used for the research of drug-resistant bacterial infections.
-
Cefonicid
0 ImagesCat. No.: HY-B1300ACAS No.: 61270-58-4Cefonicid is a long-acting cephalosporin antibiotic. Cefonicid also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid can be used for research on infections.
-
VIM-2-IN-1
0 ImagesCat. No.: HY-146637CAS No.: 2452118-54-4VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC50 values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively.
-
β-Lactamase-IN-4
0 ImagesCat. No.: HY-139751CAS No.: 1463520-91-3β-Lactamase-IN-4 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections.
-
FK-041
0 ImagesCat. No.: HY-19234CAS No.: 163009-62-9FK-041 is an orally active cephalosporin antibiotic with high affinity for penicillin-binding proteins (PBPs). FK-041 exhibits broad-spectrum antibacterial activity, exerting potent antibacterial effects against Gram-positive bacteria, most Gram-negative bacteria, anaerobes, and so on. FK-041 also shows good efficacy against some drug-resistant strains such as penicillin-resistant Streptococcus pneumoniae. FK-041 is an antibacterial agent and can be used in the research of infectious diseases.
-
Metallo-β-lactamase-IN-6
0 ImagesCat. No.: HY-143414CAS No.: 1439899-44-1Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL.
-
FPI-1602
0 ImagesCat. No.: HY-139746CAS No.: 1452460-31-9FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp..
-
Xeruborbactam isoboxil
0 ImagesCat. No.: HY-172243CAS No.: 2708983-65-5Xeruborbactam isoboxil is a beta-lactamase inhibitor.
-
Sulbactam pivoxil (Standard)
0 ImagesCat. No.: HY-108288RCAS No.: 69388-79-0Synonyms: Pivsulbactam (Standard); CP 47904 (Standard)Sulbactam pivoxil (Standard) (Pivsulbactam (Standard)) is the analytical standard of Sulbactam pivoxil (HY-108288). This product is intended for research and analytical applications. Sulbactam pivoxil (Pivsulbactam) is a prodrug of Sulbactam (HY-B0334) with oral activity. Sulbactam is a β-lactamase inhibitor with antibacterial activity. Sulbactam pivoxil is better absorbed than Sulbactam and results in higher serum levels after oral administration.
-
Cloxacillin sodium (Standard)
0 ImagesCloxacillin (sodium) (Standard) is the analytical standard of Cloxacillin (sodium). This product is intended for research and analytical applications. Cloxacillin sodium is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin sodium can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
-
NDM-1-IN-6
0 ImagesCat. No.: HY-122262CAS No.: 80570-90-7NDM-1-IN-6 (Compound 1) is a potent, selective and competitive New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a Ki of 0.72 μM. NDM-1-IN-6 has a synergistic antibacterial effect with the carbapenem antibiotic Meropenem (HY-13678). NDM-1-IN-6 is mainly used for research on NDM-1-mediated multidrug-resistant bacterial infections.
-
Brobactam
0 ImagesCat. No.: HY-119945CAS No.: 26631-90-3Brobactam is a potent synthetic wide spectrum β-lactamase inhibitor. Brobactam has antibacterial activity.
-
β-Lactamase-IN-2
0 ImagesSynonyms: EX-A4764; UUN51204β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects.
