1439899-44-1
Chemical Structure
Metallo-β-lactamase-IN-6
- CAS No.: 1439899-44-1
- Formula:C10H9N3O2
- Molecular Weight:203.20
IUPAC Name: 1-(pyridin-4-ylmethyl)-1H-imidazole-2-carboxylic acid
InChIKey: JZQNZUGEXAGUEK-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CN1CC2=CC=NC=C2)O
Biological Activity: Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL[1].
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Metallo-β-lactamase-IN-6 | Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL. | |||||||||||||||||||||
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Keywords
