2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HPPD

HPPD

4-Hydroxyphenylpyruvate dioxygenase

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-dependent, non-heme oxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. HPPD catalyzes the second step in the pathway for the catabolism of tyrosine, that is common to essentially all aerobic forms of life. In plants this pathway has an anabolic branch from homogentisate that forms essential isoprenoid redox cofactors such as plastoquinone and tocopherol.he transformation catalyzed by HPPD has both agricultural and therapeutic significance

HPPD Related Products (28):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118742R
    Benzobicyclon (Standard)
    Benzobicyclon (Standard) is the analytical standard of Benzobicyclon. This product is intended for research and analytical applications. Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds.
    Benzobicyclon (Standard)
  • HY-137910R
    Tembotrione (Standard)
    		Inhibitor
    Tembotrione (Standard) is the analytical standard of Tembotrione. This product is intended for research and analytical applications. Tembotrione is a drug that may reduce the productivity of carrots. Tembotrione has the activity of reducing carrot stem mass. Tembotrione can be used to study the total productivity of carrot . Tembotrione is a herbicide belonging to the HPPD (dioxygenase) inhibitor class with crop selectivity. Tembotrione effectively controls a variety of weeds including broadleaf and gramineous species by disrupting carotenoid synthesis, which leads to chlorophyll degradation and leaf whitening. Mixing Tembotrione with isoxaflutole or adding surfactants optimizes its efficacy and reduces phytotoxicity, with no residual impact on subsequent cruciferous crops, thus helping to increase maize grain yield. The activity of Tembotrione decreases under drought conditions, and under specific conditions (such as double-dose treatment), it may cause reversible yellowing and even yield reduction in crops such as poppy.
    Tembotrione (Standard)
  • HY-W727532
    Fenpyrazone
    		Inhibitor
    Fenpyrazone is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor as well as a post-emergence herbicide. By inhibiting the activity of HPPD, Fenpyrazone indirectly blocks carotenoid biosynthesis in plants, causing bleaching of new tissues in sensitive plants, followed by necrosis and eventual death. Fenpyrazone is used in studies on controlling annual monocotyledonous and dicotyledonous weeds in summer maize fields.
    Fenpyrazone
  • HY-W705486
    RPA 202248
    		Inhibitor
    RPA 202248 is a p-hydroxy phenyl pyruvate dioxygenase (HPPD) inhibitor and degradation product of Isoxaflutole (HY-116139). RPA 202248 demonstrates environmental persistence and undergoes transport through soil matrix and macropores to subsurface drain flow in agricultural field settings.
    RPA 202248
  • HY-W1115537
    Flusulfinam
    		Inhibitor
    Flusulfinam is a HPPD inhibitor and herbicide, with an IC50 of 0.0181 μM against Arabidopsis thaliana HPPD. Flusulfinam inhibits the catalytic activity of recombinant Arabidopsis thaliana HPPD. Flusulfinam exhibits potent herbicidal activity against barnyard grass (Echinochloa crus-galli). Flusulfinam inhibits the growth of Digitaria sanguinalis.
    Flusulfinam
  • HY-W753209
    Tolpyralate
    		Inhibitor
    Tolpyralate is a selective post-emergence herbicide and corn Herbicide. Tolpyralate inhibits 4-HPPD. Tolpyralate exhibits herbicidal activity against a variety of weeds, including the glyphosate-resistant weed Amaranthus tuberculatus.
    Tolpyralate
  • HY-175500
    HPPD-IN-5
    		Inhibitor
    HPPD-IN-5 (compound IV-45) is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with an IC50 of 0.21 μM. HPPD-IN-5 is used as a herbicide.
    HPPD-IN-5
  • HY-178026
    HPPD/PPO-IN-1
    		Inhibitor
    HPPD/PPO-IN-1 (Compound B14) is dual-functional inhibitor of HPPD and PPO with IC50s of 0.12  μM and 0.51 μM for Arabidopsis thaliana HPPD and Nicotiana tabacum PPO, respectively. HPPD/PPO-IN-1 has broad-spectrum herbicidal activity against weeds with a crop safety to peanuts and cotton. HPPD/PPO-IN-1 can be used for the development of environmentally friendly herbicides.
    HPPD/PPO-IN-1