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Cat. No.: HY-187374

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HPPD-IN-11

HPPD-IN-11 is an inhibitor of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD), with a K_i value of 0.016 μM, and exhibits herbicidal activity. HPPD-IN-11 enhances π-π interactions with Phe360 and Phe403 in the active site of AtHPPD, thereby strengthening its enzyme-binding ability. HPPD-IN-11 can be used in studies related to weed damage.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₃NO₃
Molecular Weight:337.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPPD-IN-11 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

AtHPPD

0.016 μM (Ki)

In Vitro

HPPD-IN-11 (11b) (15.625-250 g ai/ha) exhibits excellent postemergence and preemergence herbicidal activity against Solanum nigrum, Amaranthus retroflexus, Setaria viridis, and Echinochloa crus-galli at 15.625-250 g ai/ha, while showing high safety to wheat at 250 g ai/ha^[1].
HPPD-IN-11 potently inhibits purified Arabidopsis thaliana HPPD with a K_i of 0.016 μM^[1].
HPPD-IN-11 possesses molecular electronic properties including a HOMO-LUMO energy gap of 4.167 eV and a dipole moment of 6.601 D, which are associated with its biological interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 337.41
Formula C₂₁H₂₃NO₃
SMILES

CCCC1=CC=CC2=C1N=C(C)C(C(C3=C(O)CC(C)CC3=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li M, et al. Shielding Metabolic Hotspots in the Triketone-Quinoline Scaffold Yields Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Journal of agricultural and food chemistry. 2026 Jul 29;74(29):22507-22518. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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