NQO2 Inhibitor

Bisindolylmaleimide III is a protein kinase C (PKC) inhibitor with IC₅₀ values of 0.26, 5.7, and 6 μM against PKCα, PKCδ, and PKCμ, respectively. Bisindolylmaleimide III also exhibits inhibitory activity against other off-targets, with IC₅₀ values of 0.17, 1, and 2 μM against SLK, adenosine kinase (AK), and CDK2, respectively; its K_i for NQO2 is 16.5 μM. Bisindolylmaleimide III selectively binds to activated Rsk1 following EGF stimulation, and serves as a tool for detecting the activation status of intracellular Rsk1 and PKCα, as well as for functional analysis of SLK. Bisindolylmaleimide III can be used in studies of signal transduction and colorectal cancer.

Bisindolylmaleimide III hydrochloride is a protein kinase C (PKC) inhibitor with IC₅₀ values of 0.26, 5.7, and 6 μM against PKCα, PKCδ, and PKCμ, respectively. Bisindolylmaleimide III hydrochloride also exhibits inhibitory activity against other off-targets, with IC₅₀ values of 0.17, 1, and 2 μM against SLK, adenosine kinase (AK), and CDK2, respectively; its K_i for NQO2 is 16.5 μM. Bisindolylmaleimide III hydrochloride selectively binds to activated Rsk1 following EGF stimulation, and serves as a tool for detecting the activation status of intracellular Rsk1 and PKCα, as well as for functional analysis of SLK. Bisindolylmaleimide III hydrochloride can be used in studies of signal transduction and colorectal cancer.