RNA MTase Inhibitor
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MY-1B
0 ImagesMY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.
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SA91-0178
0 ImagesSA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases.
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RNMT-IN-1
0 ImagesCat. No.: HY-186197CAS No.: 1381321-59-0RNMT-IN-1 is a RNMT inhibitor with a pIC50 of 5.5. RNMT-IN-1 can be used for research on various cancers.
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Antibacterial agent 355
0 ImagesCat. No.: HY-184445Antibacterial agent 355 is a bacterial tRNA (m1G37) methyltransferase (TrmD) inhibitor with an IC50 of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC50 of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections.
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RNA MTase-IN-1
0 ImagesCat. No.: HY-175228RNA MTase-IN-1 (Compound 47) is a RNA methyltransferase (RNA MTase) inhibitor with an IC50 of 68 μM for 16S rRNA (m1A1408) methyltransferase (NpmA). RNA MTase-IN-1 has a significant inhibitory activity against pathogen-associated aminoglycoside-resistance. RNA MTase-IN-1 can be used for resistant bacterial infections research.
