2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. TrxR
  5. TrxR2 Isoform
  6. TrxR2 Inhibitor

TrxR2 Inhibitor

TrxR2 Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-182324
    TrxR2-IN-1
    		Inhibitor
    TrxR2-IN-1 is a thioredoxin reductase 2 (TrxR2) inhibitor with an IC50 value of 0.83 μM. TrxR2-IN-1 accumulates in mitochondria, impairs mitochondrial function and membrane potential, increases reactive oxygen species (ROS) levels, activates ASK1-mediated caspase-dependent apoptosis (apoptosis), induces G2/M cell cycle arrest, and inhibits cancer cell migration. TrxR2-IN-1 can be used in the research of hepatocellular carcinoma.